Pharmaceutical composition comprising cytisine
AssigneeAdamed Pharma S.A.
InventorsMagdalena Lysiak, Mariola Zarzycka, Joanna Rzasa
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Abstract
The present invention relates to a stabilized composition with significantly improved shelf-life stability. More particularly, the present invention relates to a stable liquid aqueous pharmaceutical composition comprising cytisine or a pharmaceutically acceptable salt thereof, at least one antioxidant selected from the group consisting of a sulfite, bisulfite, and metabisulfite compound. The present invention relates also to a use of at least one antioxidant selected from the group consisting of a sulfite, bisulfite, and metabisulfite compound for the stabilization of a liquid aqueous pharmaceutical composition comprising cytisine.
Claims10
A liquid aqueous pharmaceutical composition comprising cytisine or a pharmaceutically acceptable salt thereof, at least one antioxidant selected from the group consisting of a sulfite, bisulfite, and metabisulfite compound, wherein the antioxidant is present in an amount of from 0.01% to 2.0% by weight, based on the total weight of the pharmaceutical composition and wherein the pH of the said liquid aqueous composition is in the range of 5.0-7.0.
Use of at least one antioxidant selected from the group consisting of a sulfite, bisulfite, and metabisulfite compound for the stabilization of a liquid aqueous pharmaceutical composition comprising cytisine, wherein the antioxidant is present in an amount of from 0.01% to 2.0% by weight, based on the total weight of the pharmaceutical composition, and wherein the pH of said liquid aqueous composition is in the range of 5.0-7.0.
Dependencies are inferred from the claim text.