Composition and products comprising an antibiotic and a glucocorticoid for treating mastitis

A method for the treatment or the prophylaxis of bacterial infectious diseases in infected lactating ruminants, comprising administering to said infected lactating ruminants a composition comprising, in a pharmaceutically acceptable medium, (i) at least one antibiotic chosen from penicillin, its derivatives and its salts, and (ii) at least one glucocorticoid, wherein penicillin and its derivatives are chosen from compounds of formula (I):

• wherein R is an aralkyl, a phenoxymethyl radical, an alkyl radical having 1 to 10 carbon atoms or an alkenyl radical having 2 to 10 carbon atoms,
• wherein said composition does not comprise any zirconium containing compound.

A method for enhancing the removal of an antibiotic chosen from penicillin, its derivatives and its salts, in an infected lactating ruminant treated by said antibiotic, comprising administering to said infected lactating ruminant a composition comprising, in a pharmaceutically acceptable medium, hydrocortisone aceponate, wherein enhancing the removal of an antibiotic chosen from penicillin, its derivatives and its salts means that the antibiotic residue in an infected lactating ruminant treated by said antibiotic and by hydrocortisone aceponate is below maximum residue limit within at least 6 h, wherein penicillin and its derivatives are chosen from compounds of formula (I):

• wherein R is an aralkyl, a phenoxymethyl radical, an alkyl radical having 1 to 10 carbon atoms or an alkenyl radical having 2 to 10 carbon atoms.

A Method for lowering somatic cell count in the milk of a lactating ruminant infected with a mastitis-causing organism, which comprises administering to said infected lactating ruminant a composition comprising, in a pharmaceutically acceptable medium, (i) at least one antibiotic chosen from penicillin, its derivatives and its salts, and (ii) at least one glucocorticoid, wherein lowering somatic cell count (SCC) in the milk means lowering SCC as compared to the SCC in the milk when said antibiotic is administrated alone i.e. without any glucocorticoid to the infected lactating ruminant, wherein penicillin and its derivatives are chosen from compounds of formula (I):

• wherein R is an aralkyl, a phenoxymethyl radical, an alkyl radical having 1 to 10 carbon atoms or an alkenyl radical having 2 to 10 carbon atoms.