Composition for preventing or treating inflammatory skin diseases,containing 1h-pyrazole-3-amide compound derivative

A method of preventing or ameliorating an inflammatory skin disease comprising administering a health functional food composition;

• comprising a 1H-pyrazole-3-amide compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient to a subject in need of preventing or ameliorating the inflammatory skin disease:
• wherein, in the Chemical Formula 1,
• A is
• R1 is hydrogen, (C1-C10)alkyl, (C3-C7) cycloalkyl, (C6-C20) aryl, or (C6-C20) ar (C1-C10)alkyl;
• R2 and R3 are independently hydrogen, (C1-C10)alkyl, (C6-C20) aryl, (C6-C20) ar (C1-C10)alkyl, (C3-C7) cycloalkyl, (C3-C7) heterocycloalkyl comprising one or more heteroatoms selected from N, O, and S, adamantyl, piperidino, or pyrrolidino or R2 and R3 may be connected to (C3-C7)alkylene to form a ring, and one or more carbon atoms in the alkylene may be substituted with NR6, O, or S;
• R4 and R5 are each independently hydrogen, (C1-C10)alkyl, (C3-C7) cycloalkyl, or (C6-C20) aryl;
• R6 is hydrogen, (C1-C10)alkyl, or (C1-C10)alkoxycarbonyl;
• and
• the alkyl, aryl, aralkyl, cycloalkyl, adamantly, or heterocycloalkyl in the R1, R2, and R3 may be further substituted with one or more substituents selected from halogen, (C1-C10)alkyl, halo (C1-C10)alkyl, (C1-C10)alkoxy, mono or di-(C1-C10)alkylamino, mono or di-(C6-C20) arylamino, (C3-C7) cycloalkyl, (C2-C20) heteroaryl, hydroxy, (C3-C7) heterocycloalkyl comprising one or more heteroatoms selected from N, O, and S, pyrrolidino, or piperidino.