Methods of treating breast hyperplasia using tezacaftor
AssigneeJiangsu Bioscene Pharmaceutical Co., Ltd.
InventorsJian HOU, Zhengtao ZONG, Ningpu YU, Zaixin CHEN
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Abstract
The present invention relates to a method for treating breast hyperplasia in a subject in need thereof, comprising administering to the subject tezacaftor, or a pharmaceutically acceptable salt, solvate, or hydrate thereof. Non-clinical pharmacodynamic studies demonstrated that, in a rat model of breast hyperplasia, tezacaftor significantly reduced nipple diameter, nipple height, and uterine index, alleviated breast hyperplasia, and improved serum E2 and PROG levels. These results indicate that tezacaftor is useful for treating breast hyperplasia.
Claims15
A method of treating breast hyperplasia in a subject in need thereof, comprising administering to the subject an effective amount of tezacaftor or a pharmaceutically acceptable salt thereof, a solvate of any of the foregoing, or a hydrate of any of the foregoing.
A pharmaceutical composition for use in treating breast hyperplasia comprising tezacaftor or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.