Compounds, process of production of compounds, enriched extract, enriched extract active fractions, enriched extract process of production, method for selecting vegetal biomass for enriched extract production, composition and use for treatment of immunological disorders

A method of treating an immune disorder comprising administering to a patient in need thereof an effective amount of at least one compound of general formula (I), (II) and/or (III) below in an amount sufficient to provide immunosuppressive effect, wherein general formula (I), (II) and/or (III) are as follows:

• wherein R corresponds to H, OH, OGlyc (Glycoside);
• R1, R1′, R1″ correspond to H, OH;
• R2 corresponds to H, COOH, COOCH3, CH3, CHO;
• R3 corresponds to H, OH, CH3;
• R4, R4′ correspond to H, OH, CH2OH, CH3;
• R5, R5′ correspond to H, CH3, COOCH3, CHO, CH2OH;
• Re corresponds to CHO, COOH, COOCH3;
• R7 corresponds to H, CH3;
• R8, R8′, R8″ correspond to CHO, CH3, CH2OH, COOH and the dashed bonds represent single (C—C) or double (C═C) bonds between carbons (up to two double bonds per structure), and wherein R1 may be absent or correspond to H or OH.

A process for producing active compounds comprising subjecting at least one ipolamiide compound to heating at high temperatures in a suitable solvent for a time sufficient to obtain the ipolamiide derivatives of formula (I), (II) and/or (III) as follows:

• wherein R corresponds to H, OH, OGlyc (Glycoside);
• R1, R1′, R1″ correspond to H, OH;
• R2 corresponds to H, COOH, COOCH3, CH3, CHO;
• R3 corresponds to H, OH, CH3;
• R4, R4′ correspond to H, OH, CH2OH, CH3;
• R5, R5′ correspond to H, CH3, COOCH3, CHO, CH2OH;
• R6 corresponds to CHO, COOH, COOCH3;
• R7 corresponds to H, CH3;
• R8, R8′, R8″ correspond to CHO, CH3, CH2OH, COOH and the dashed bonds represent single (C—C) or double (C═C) bonds between carbons (up to two double bonds per structure), and wherein R1 may be absent or correspond to H or OH.

An extract obtained from the plants of the genus Stachytarpheta comprising at least one compound of general formula (I), (II) and/or (III) as follows:

• wherein R corresponds to H, OH, OGlyc (Glycoside);
• R1, R1′, R1″ correspond to H, OH;
• R2 corresponds to H, COOH, COOCH3, CH3, CHO;
• R3 corresponds to H, OH, CH3;
• R4, R4′ correspond to H, OH, CH2OH, CH3;
• R5, R5′ correspond to H, CH3, COOCH3, CHO, CH2OH;
• R6 corresponds to CHO, COOH, COOCH3;
• R7 corresponds to H, CH3;
• R8, R8′, R8″ correspond to CHO, CH3, CH2OH, COOH and the dashed bonds represent single (C—C) or double (C═C) bonds between carbons (up to two double bonds per structure), and wherein R1 may be absent or correspond to H or OH.