Novel solutions
OwnerLars EDVINSSONinventor
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Abstract
The invention provides a pharmaceutical composition that is an aqueous solution comprising compound (I) (also known as U0126) or a pharmaceutically-acceptable salt thereof, at a concentration of 50 to 200 μM and wherein the solution further comprises 0.2 to 1.0% (v/v) polyoxyethylene castor oil. The composition finds particular use in the treatment of ischemic damage (in particular subarachnoid hemorrhage) in a human patient by direct injection into the brain. Uses of the composition, unit doses containing the composition and methods of using the composition are also disclosed.
Claims19
A pharmaceutical composition that is an aqueous solution comprising compound (I)
- or a pharmaceutically-acceptable salt thereof, at a concentration of 50 to 200 μM, wherein the solution further comprises 0.2 to 1.0% (v/v) polyoxyethylene castor oil.
An aqueous solution comprising compound (I)
- or a pharmaceutically-acceptable salt thereof, at a concentration of 50 to 200 μM, wherein the solution further comprises 0.2 to 1.0% (v/v) polyoxyethylene castor oil.
11-13. (canceled)
A method for the treatment of ischemic damage comprising administering compound (I)
- or a pharmaceutically-acceptable solvate of salt thereof to a human patient wherein ischemic damage is treated in the patient.
A method of manufacture of a medicament for treatment of ischemic damage comprising obtaining compound (I)
- or salt thereof and formulating it into an aqueous solution.
A unit dose comprising compound (I)
- or a pharmaceutically-acceptable solvate of salt thereof wherein the unit dose has a volume of 1 to 10 mL.
A pharmaceutically acceptable solution comprising a polyoxyethylated castor oil and artificial cerebrospinal fluid.
A method of using Compound (I) to treat an ischemic disorder in a human comprising:
- obtaining Compound (I):
- or a pharmaceutically-acceptable solvate of salt thereof that has been formulated into a solution appropriate for direct injection into the brain of a human;
- and
- injecting the solution directly into the brain of a human;
- wherein an ischemic disorder is treated in the human.
Dependencies are inferred from the claim text.