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AssigneeUniversidad De Granada
InventorsJosé Carlos PRADOS SALAZAR, José Manuel DELGADO LÓPEZ, Francisco QUIÑONERO MUÑOZ, Belén PARRA TORREJÓN, Gloria Belén RAMÍREZ RODRÍGUEZ, Consolación MELGUIZO ALONSO, Raúl ORTIZ QUESADA, Cristina JIMÉNEZ LUNA
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Biocompatible and biodegradable nanoparticles based on amorphous calcium phosphate containing ascorbic acid and anti-tumor agents. The use of these nanoparticles as highly stable nanocarriers of these drugs improves their effectiveness in terms of bioavailability, cytotoxicity, induction of apoptosis, inhibition of cell migration, tumor growth and survival. These nanoparticles may be obtained by mixing a solution of CaCl2 and Na3C6H5O7 and a solution of K2HPO4 and Na2CO3, adsorbing one or more PARP inhibitors, and adsorbing ascorbic acid.
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A method for treating an individual having cancer, the method comprising:
A nanoparticle based on amorphous calcium phosphate comprising ascorbic acid and one or more PARP inhibitor.
A method for obtaining a nanoparticle based on amorphous calcium phosphate comprising ascorbic acid and one or more PARP inhibitor, the method comprising:
Dependencies are inferred from the claim text.