Polymeric microparticles encapsulated with active pharmaceutical ingredients and related methods of use and manufacture
AssigneeThe General Hospital Corporation
InventorsOrhun Muratoglu, Dinesh Dhamecha, Mehmet D. Asik, Ebru Oral Bhatia
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Abstract
Methods of delivering pharmaceutically active ingredients to patients and related methods of treatment are provided involving administering form of an active pharmaceutical ingredient that is inside polymeric microparticles. Related methods of manufacturing the microparticles with microfluidic devices are disclosed using double emulsion and/or single emulsion techniques. Hydrophilic and hydrophobic active ingredients may be provided in the polymeric microparticles and characteristics such as the in vivo release profile of the active ingredient may be tuned as desired.
Claims42
A method of treating a patient comprises administering to said patient a therapeutically effective amount of an injectable formulation comprising microparticles, the microparticles comprising at least one active pharmaceutical ingredient and a poly(lactic-co-glycolic) acid copolymer (PLGA) matrix, said microparticles manufactured by microfluidic devices.
A method of making microparticles comprising at least one infection management active pharmaceutical ingredient the method comprising the steps of
- delivering an organic phase fluid to a first channel on a microfluidic device, the organic phase comprising a solvent and a polymer material;
- delivering a first aqueous phase fluid to a second channel on the microfluidic device, the first aqueous phase comprising water;
- wherein an active pharmaceutical ingredient is provided in either or both of the organic phase fluid and the first aqueous phase fluid, and the first channel and the second channel on the microfluidic device intersect at a first junction so that the organic phase fluid and the first aqueous phase fluid come in contact to form an emulsion, enter a third channel and form microparticles in the fluid;
- and
- removing the fluid comprising microparticles from the microfluidic device.
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A microfluidic device for producing emulsions comprising:
- at least one microchannel connected to a flow source, the microchannel having a completely or partially void structure to form a cavity, the cavity allowing fluids, dispersions and/or emulsions to pass through the cavity, wherein at least one of the width, length or height of the channel is a maximum 1000 micrometers,
- at least two fluid inlets connected to the microchannel and allowing fluid to enter the microchannel,
- at least one fluid outlet connected to the channel and enables the fluid to exit from the microchannel,
- at least two flow focusing junctions located between the fluid inlet and the fluid outlet in the channel, which changes the flow properties of the fluid in the channel to form emulsions in the channel.
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Dependencies are inferred from the claim text.