Manufacturing process for hybrid lipid particles
AssigneeSisaf Limited
InventorsRoghieh Suzanne SAFFIE-SIEBERT, Nasrollah TORABI-POUR, Ashkan DEHSORKHI
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Abstract
Method of manufacturing an aqueous suspension of hybrid lipid particles comprising the steps of mixing one or more lipids in a solvent or solvent mixture and a suspension of particles of inorganic material in a solvent or solvent mixture, into an aqueous medium; then passing the mixture resulting from Step A through the pores of an extrusion membrane, wherein the hybrid lipid particles have a mean diameter at least two times larger than the mean diameter of the particles of inorganic material. Related product, methods of treatment and medical application.
Claims33
A method of manufacturing an aqueous suspension of hybrid lipid particles comprising the steps of:
- A. mixing one or more lipids in a solvent or solvent mixture and a suspension of particles of inorganic material in a solvent or solvent mixture, into an aqueous medium;
- then
- B. passing the mixture resulting from Step A through the pores of an extrusion membrane,
- wherein the hybrid lipid particles have a mean diameter at least two times larger than the mean diameter of the particles of inorganic material.
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An aqueous suspension of hybrid lipid particles having a mean diameter of between 50 and 150 nm, the hybrid lipid particles comprising a mixture of one or more cationic lipids or ionisable lipids with one or more further lipids selected from neutral lipids and polar lipids, and optionally one or more additional lipid components, the hybrid lipid particles comprising particles of inorganic material (for example, hydrolysable silicon particles) having a mean diameter of at least one half of the mean diameter of the hybrid lipid particles, wherein the weight ratio of the particles of inorganic material to lipid is between 1:2 and 1:100.
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A lyophilized powder of hybrid lipid particles or liposomal lipid particles having a mean diameter of between 50 and 150 nm, the hybrid lipid particles or liposomal lipid particles comprising a mixture of one or more cationic lipids or ionisable lipids with one or more further lipids selected from neutral lipids and polar lipids, and optionally one or more additional lipid components, the hybrid lipid particles or the liposomal lipid particles comprising particles of inorganic material having a mean diameter of at least one half of the mean diameter of the liposomal lipid particles, wherein the weight ratio of the particles of inorganic material to lipid is between 1:2 and 1:100 and wherein the hybrid lipid particles or liposomal lipid particles further comprise one or more active compounds, at least a portion of which are encapsulated within the interior of the hybrid lipid particles or liposomal particle.
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Dependencies are inferred from the claim text.