Microneedle Particles and Methods of Incorporating a Substance Into or Onto Microneedle Particles

(canceled)

10-11. (canceled)

A composition comprising:

• a plurality of STAR particles which are configured to mechanically disrupt a biological tissue surface,
• wherein the STAR particles have a heterogeneous structure comprising (i) a first substance of interest (SOI) contained within a shell of carrier material, (ii) one or more layers of a first SOI stacked with one or more layers of a carrier material;
• or (iii) dispersed domains containing a first SOI, which optionally consists of a suspension of solid SOI-containing particles, dispersed in a solid medium of carrier material.

(canceled)

A method of making STAR particles, comprising:

• forming a plurality of porous STAR particles;
• and then
• contacting the formed porous STAR particles with a liquid, gas, solid, or any combination thereof, comprising a substance of interest (SOI) in a manner such that the liquid, gas, solid, or a combination of two or three phases thereof is incorporated into pores of the STAR particles.

A method of making STAR particles, comprising:

• forming a plurality of STAR particles;
• and then
• adsorbing, absorbing, or spraying a solid form of a substance of interest (SOI) into/onto the STAR particles.

24-50. (canceled)

A composition comprising:

• a plurality of STAR particles which comprise a first substance of interest (SOI) which comprises (i) a compound which absorbs UV radiation or otherwise is effective as a sunscreen, (ii) a perfume and/or (iii) an insect repellant.

52-58. (canceled)