System for treating, preventing and/or replacing a heart valve, in particular an inflamed, infected, thrombosed or degenerated heart valve
AssigneeDevie Medical GmbH
InventorsHans-Reiner Figulla, Raphael Andreas Seidel, Sharath Chandra Chavalla
Life of this patent
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Abstract
The invention relates to catheter-guided, active substance-releasing heart valve prostheses which are characterized by special design features such as for example compartmentalization clips that can be folded down, diffusion-impermeable structures and active substance-releasing matrices in order to locally treat infectious heart valve diseases. The heart valve prosthesis according to the invention replaces the heart valve function of the infected valve and at the same time treats the infection by therapy by a local release of active substances.
Claims14
1-54. (canceled)
A catheter for introducing an anchoring for a heart valve prosthesis into a body of a patient, the catheter comprising:
- a handle;
- and
- a catheter tip configured to be manipulated via the handle of the catheter such that the heart valve prosthesis is incrementally releasable from the catheter tip,
- wherein the anchoring comprises:
- a stent framework configured for attaching at least two heart valve leaflets to an inner side in an implanted state, the stent framework having a proximal end and a distal end;
- and
- at least two compartmentalization clips, each one of the at least two compartmentalization clips being connected with the stent framework and at least partially overlapping the stent framework in a primary form of the anchoring to hold and clamp at least one of native heart valve leaflets and infectious deposits, infectious vegetation, thrombotic deposits, and thrombotic vegetation of the native heart valve between the stent framework and the at least one of the at least two compartmentalization clips when the anchoring is in the implanted state,
- wherein the catheter aids in introducing the anchoring minimally invasively into a body of a patient in a delivery form and transforming the anchoring into an implanted state at an implantation site on the diseased heart valve, and
- wherein the catheter tip is of a divided design such that the at least two compartmentalization clips are incrementally released one after another from the catheter tip and the stent framework is then released after the at least two compartmentalization clips.
An anchoring for a heart valve prosthesis for one of treatment, prevention, and replacement of a heart valve, in particular one of an inflamed, infected, thrombosed, and degenerated heart valve, the anchoring comprising:
- a stent framework configured for attaching at least two heart valve leaflets to an inner side, wherein the stent framework has a proximal end and a distal end;
- and
- at least two compartmentalization clips, each one of the at least two compartmentalization clips being connected with the stent framework at a first end region and having a free second end region, wherein the anchoring exhibits a primary form and is able to be reversibly transformed into a delivery form for minimally invasive introduction of the anchoring into a body of a patient by at least one of elastic deformation and compression of at least one of regions and elements of the anchoring,
- wherein the compartmentalization clips are arcuately shaped between the first and second end regions in the primary form of the anchoring,
- wherein the compartmentalization clips are configured to be elastically folded over such that the compartmentalization clips extend in a substantially flat manner between the first and second end regions in the delivery form of the anchoring,
- wherein the anchoring further comprises a separation structure connected with the stent framework and the compartmentalization clips such that the separation structure separates areas of native heart valve leaflets, intended to be treated, from a bloodstream when the anchoring is in an implanted state, and
- wherein the anchoring is designed to hold and clamp at least one of native heart valve leaflets and, infectious deposits, infectious vegetation, thrombotic deposits, and thrombotic vegetation of the diseased heart valve between the stent framework and the compartmentalization clips when the anchoring is in an implanted state.
An anchoring for a heart valve prosthesis for one of treatment, prevention, and replacement of a heart valve, in particular an inflamed, infected, thrombosed, and degenerated heart valve, the anchoring comprising:
- a stent framework configured for attaching at least two heart valve leaflets to an inner side, wherein the stent framework has a proximal end and a distal end;
- and
- at least two compartmentalization clips, each one of the at least two compartmentalization clips being connected with the stent framework,
- wherein each one of the at least two compartmentalization clips being configured to at least partially overlap the stent framework in a primary form of the anchoring to hold and clamp at least one of native heart valve leaflets and infectious deposits, infectious vegetation, thrombotic deposits, and thrombotic vegetation of the native heart valve between the stent framework and at least one of the at least two compartmentalization clips,
- wherein the anchoring exhibits a primary form,
- wherein the anchoring is configured to be reversibly transformable, by at least one of elastic deformation and compression of at least one of regions and elements of the anchoring, into a delivery form for minimally invasive introduction of the anchoring into a body of a patient,
- wherein each one of the at least two compartmentalization clips includes a first end region, which first end region is connected with the stent framework, and a free second end region,
- wherein each one of the at least two compartmentalization clips is able to be folded over such that the at least two compartmentalization clips extend in a substantially flat manner between the first and second end regions in the delivery form of the anchoring,
- wherein the anchoring further comprises a separation structure connected with the stent framework and the at least two compartmentalization clips such that, when in an implanted state, the separation structure separates areas of native heart valve leaflets to be treated from a bloodstream,
- wherein the separation structure includes a first structural surface directed radially inward toward a longitudinal axis of the anchoring in the delivery form of the anchoring, and a second structural surface opposite from the first structural surface,
- wherein the second structural surface comprises a matrix releasably containing at least one of antibiotic, antithrombotic, and thrombolytic agents, and
- wherein the anchoring is designed to hold and clamp at least one of native heart valve leaflets and, infectious deposits, infectious vegetation, thrombotic deposits, and thrombotic vegetation of the diseased heart valve between the stent framework and the compartmentalization clips when the anchoring is in an implanted state.
Dependencies are inferred from the claim text.