Wearable biosensor device with improved cover and improved flexibility and conformance

A wearable biosensor device comprising

• a. an extended cover comprising an electrically nonconductive material and facing a user's skin, and further comprising an upper surface integral with a lower surface comprising a set of first openings, the upper surface and the lower surface being joined by a slope,
• b. a microneedle array comprising a substrate integral with microneedles, the microneedle array also comprising the electrically nonconductive material, and each of the microneedles comprising a tip, a body region and a base at the substrate, and the microneedles placed in complimentary position to the set of first openings in the extended cover, so that at least the tip of each of the microneedles rises beyond the lower surface of the extended cover, and an electrically conductive layer covers the microneedles and at least a portion of the substrate,
• c. at least one chemical layer on the electrically conductive layer on at least one of the microneedles functionalized as a working electrode to interact with at least one target analyte in a biofluid beneath the user's skin and to produce electrical signals associated with analyte reactions detectable at the working electrode, and
• d. an electronics unit positioned underneath the microneedle array connected electrically to the electrically conductive layer on the microneedles by a plurality of electrical interconnections.