Method for multi-modal diagnostic

A method for optical coherence tomography angiography (OCTA), the method comprises:

• performing optical coherence tomography (OCT) measurement sessions of a region of an in-vivo tissue;
• wherein the performing of the OCT measurements sessions comprises illuminating, by aera illumination, the region and collecting interference patterns resulting from the illumination by a two dimensional (2D) array of radiation sensors;
• processing OCT measurement sessions information obtained by the OCT measurement sessions to identify within the OCT measurement sessions information 3D segments that fluctuate at a rate that corresponds to a heart rate;
• and
• providing information regarding blood within the region of an in-vivo tissue, based on the identified 3D segments.

A non-transitory computer readable medium for optical coherence tomography (OCT), the non-transitory computer readable medium that stores instructions for:

• performing a measurement session that comprises performing measurement iterations of a region of an in-vivo tissue, using a swept illumination source;
• wherein each measurement iteration comprises:
• providing sets of pulses (SOPs) of radiation to an interferometer;
• wherein pluses of each SOP have a same wavelength range, and at least some of the SOPs differ from each other by their wavelength range;
• splitting, by the interferometer, the SOPs to a first path SOPs and a second path SOPs;
• generating by the interferometer, interference patterns that represents an interference between (i) the first path SOPs, following a propagation of the first path SOPs along a first path and an interaction of the first path SOPs with the region of the in-vivo-tissue, and (ii) the second path SOPs, following a propagation of the second path SOPs though a second path and an interaction of the second path SOPs with a reference arm of the interferometer;
• wherein a selected path out of the first path and the second path introduces phase changes between pulses of a same set;
• and
• generating signals indicative of the interference pattern by two dimensional (2D) array of sensing related elements of a sensing unit;
• and
• processing the signals;
• wherein the processing of the signals comprises determining depth information regarding the region of an in-vivo tissue.

A non-transitory computer readable medium for optical coherence tomography angiography (OCTA), the non-transitory computer readable medium that stores instructions for:

• performing optical coherence tomography (OCT) measurement sessions of a region of an in-vivo tissue;
• wherein the performing of the OCT measurements sessions comprises illuminating, by aera illumination, the region and collecting interference patterns resulting from the illumination by a two dimensional (2D) array of radiation sensors;
• processing OCT measurement sessions information obtained by the OCT measurement sessions to identify within the OCT measurement sessions information 3D segments that fluctuate at a rate that corresponds to a heart rate;
• and
• providing information regarding blood within the region of an in-vivo tissue, based on the identified 3D segments.

A device for optical coherence tomography (OCT), the device comprising:

• an interferometer;
• a swept radiation source;
• a sensing unit that comprises a two dimensional (2D) array of sensing related elements;
• a processor;
• and
• a controller that is configured to control a performing of a measurement session that comprises performing measurement iterations of a region of an in-vivo tissue, using a swept illumination source;
• wherein during each measurement iteration:
• the swept radiation source is configured to provide sets of pulses (SOPs) of radiation to the interferometer;
• wherein pluses of each SOP have a same wavelength range, and at least some of the SOPs differ from each other by their wavelength range;
• the interferometer is configured to:
• split the SOPs to a first path SOPs and a second path SOPs;
• generate interference patterns that represents an interference between (i) the first path SOPs, following a propagation of the first path SOPs along a first path and an interaction of the first path SOPs with the region of the in-vivo-tissue, and (ii) the second path SOPs, following a propagation of the second path SOPs though a second path and an interaction of the second path SOPs with a reference arm of the interferometer;
• wherein a selected path out of the first path and the second path introduces phase changes between pulses of a same set;
• and
• the 2D array of sensing related elements is configured to generate signals indicative of the interference pattern;
• wherein the processor is configured to process the signals;
• and to determine depth information regarding the region of an in-vivo tissue.

A device for optical coherence tomography angiography (OCTA), the device comprises:

• an interferometer;
• a radiation source;
• a sensing unit that comprises a two dimensional (2D) array of sensing related elements;
• a processor;
• and
• a controller;
• wherein the device is configured to perform optical coherence tomography (OCT) measurement sessions of a region of an in-vivo tissue;
• wherein the performing of the OCT measurements sessions comprises illuminating the region, by aera illumination, under a control of the controller, and using the radiation source;
• feeding radiation from the region to the interferometer, generating interference patterns by the interferometer, and collecting interference patterns resulting from the illumination by the 7D array of radiation sensors;
• wherein the processor is configured to
• process OCT measurement sessions information obtained by the OCT measurement sessions to identify within the OCT measurement sessions information 8D segments that fluctuate at a rate that corresponds to a heart rate;
• and
• provide information regarding blood within the region of an in-vivo tissue, based on the identified 8D segments.