Systems and methods for generation of hyperpolarized materials

Abstract

Methods for increasing the concentration of a hyperpolarized molecule of interest in solution are disclosed. The hyperpolarized molecule of interest is prepared in an organic solution. A portion of the organic solution is rapidly evaporated to increase its concentration in the solution while maintaining sufficient nuclear spin polarization. The hyperpolarized molecule of interest is then used in an MRI or NMR experiment. Methods for increasing the nuclear spin polarization in molecules of interest polarized by SABRE methods are disclosed. An at least partially deuterated molecule of interest is placed in a magnetic field having a mean magnetic field strength of at most about 2 T. The molecule of interest forms a coordination complex with a SABRE catalyst or pre-catalyst and parahydrogen in solution. An oscillating magnetic field is applied to transfer spin order from the parahydrogen to the molecule of interest, thereby increasing the nuclear spin polarization in the molecule of interest.

Dependencies are inferred from the claim text.