Bioassay with a large dynamic range based on microlasers

Abstract

A bioassay device having a dynamic detection range to quantify at least one biological species includes a region receiving a fluid sample optionally including the biological species. The device includes a plurality of microlasers with at least one optical cavity and a plurality of microunits. Each microunit comprises at least one added lasing energy responsive species (a gain or a lossy medium) to modulate lasing emissions when energy is directed at the microlasers/microunits. Each microunit comprises a targeting component capable of binding with at least one target biological species in the fluid sample. A respective level of lasing emissions generated by the plurality of microunits relates to an amount of the energy directed at the plurality of microlasers and indicates a quantity of the at least one target biological species in the fluid sample. Methods for quantifying at least one target biological species in a fluid sample are also provided.

Dependencies are inferred from the claim text.