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AssigneeScorpido Photonics Inc.
InventorDmitri Lapotko
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The invention relates to all-optical methods and systems for diagnosis of disease (for example, cancer) with the cell-level precision and in real time in ex Vivo tissue samples (biopsies or surgical specimens) through the generation and detection of disease-specific plasmonic nanobubbles (“PNBs”). PNBs are on-demand short laser pulse-activated non-stationary vapor nanobubbles. A system for diagnosing the disease comprises a device which optically generates and detects PNBs in a sample. A method comprises (a) incubating a sample with plasmonic nanoparticles; (b) placing a sample into the PNB system: (c) generating PNBs with a pump laser pulse; (d) detecting PNBs optically in a sample; and (e) diagnosing the disease through analysis of the detected optical signal in response to a laser pulse. PNB system and method provide a rapid micro-analysis of ex viva samples, solid or liquid, with a single cell sensitivity.
A method comprising (a) incubating a sample with plasmonic nanoparticles, (b) mounting the sample onto a holder, (c) exposing the sample to a pump laser, (d) exposing the sample to a probe laser, and (e) diagnosing the sample based upon the signal of the probe laser beam.
A system for diagnosing a sample ex vivo comprising one or more plasmonic nanoparticles, a sample holder, a pump laser, a probe laser, a photodetector for capturing probe laser light from the sample, a computer, and a software module on the computer for comparing the probe laser light before and during exposure to a single pulse by the pump laser.
Dependencies are inferred from the claim text.