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US 2026/0210940 A1Published application
Immune cell organoid co-cultures
AssigneesKoninklijke Nederlandse Akademie van Wetenschappen, HUB Organoids IP B.V.
InventorsKai Kretzschmar, Jotam Elazar Bar-Ephraim, Johannes Carolus Clevers, Sylvia Fernandez-Boj, Robert Vries
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Abstract
The present invention provides co-cultures of organoids and immune cells, and methods of using these to identify agents for treating diseases.
Claims21
1-78. (canceled)
A method for preparing an in vitro immune disease organoid co-culture, wherein the method comprises:
- a. preparing at least one immune disease organoid by culturing disease epithelial cells in an organoid culture medium, and preparing immune cells by culturing the immune cells in an immune cell expansion medium;
- and
- b. preparing the immune disease organoid co-culture by culturing the at least one immune disease organoid with the immune cells in a co-culture medium.
An in vitro immune disease organoid co-culture comprising:
- a. at least one immune disease organoid comprising disease epithelial cells;
- b. immune cells;
- and
- c. a co-culture medium.
1 more element
Dependencies are inferred from the claim text.