Devices and methods for optical analysis of biological samples

A device for determining one or more analytes in a biological sample, the device comprising:

• a motor configured to rotate a disc having one or more first wells at a first common radius relative to a rotational axis of the disc, wherein each of the one or more first wells contains one or more reagents disposed therein and is configured to receive an aliquot of a fluid comprising one or more components of the biological sample;
• one or more illumination sources configured to illuminate the one or more first wells during a detection period while the motor is rotating the disc;
• and
• one or more detectors configured to detect one or more optical signals from the one or more first wells during the detection period while the motor is rotating the disc, wherein each of the one or more detectors produces at least one reading for each of the one or more first wells per revolution of the disc during the detection period, thereby facilitating determination of the one or more analytes in the biological sample.