Point-of-care devices and methods for biopsy assessment

A point-of-care device for biopsy assessment, the device comprising:

• a receptacle configured to receive a biological sample therein or thereon;
• a light source configured to:
• emit light at a single or plurality of wavelengths between about 200 nm to about 1100 nm and illuminate at least a portion of the biological sample;
• an image sensor configured to:
• receive at least a portion of the emitted light and convert at least the portion of the emitted light to a signal;
• a memory configured to store processor-executable instructions;
• and
• a processor coupled to the memory and the image sensor, wherein the instructions, when executed by the processor, cause the processor to:
• receive the signal from the image sensor;
• convert the signal into a first image representing at least the portion of the biological sample;
• identify a first cell type as a nucleated cell represented in the first image and associated with at least the portion of the biological sample, wherein a nucleic acid of the first cell type absorbs light in a first wavelength range in the plurality of wavelengths;
• determine whether a quality of the biological sample is above a predefined threshold based on the identified first cell type;
• and
• when the quality is above the predefined threshold, generate an indication of an adequacy and/or diagnostics of the biological sample.