Back to results
US 2026/0209801 A1Published application
mRNA INDUCED EXPRESSION OF BONE MORPHOGENIC PROTEIN AND RECEPTOR AND METHODS RELATED THERETO
OwnerAlexander DAY, Bradford MULLINinventors
Life of this patent
Estimating the term…
Abstract
Methods and treatments including preparing a synthetic messenger ribonucleic acid (mRNA) encoding at least for a bone morphogenetic protein (BMP) and/or a BMP receptor. The synthetic mRNA is lipid-solubilized in a lipid or lipid derivative carrier. Intraoperatively, a bone harvest sample is obtained and incubated with the lipid-solubilized mRNA. The bone harvest sample internalizes at least a portion of the lipid-solubilized mRNA, thereby forming activated BMP and/or BMPR material. The activated BMP and/or BMPR material may be delivered intraoperatively to a bone fusion bed.
Claims20
A method comprising:
- preparing a synthetic messenger ribonucleic acid (mRNA) encoding at least for a bone morphogenetic protein receptor (BMPR);
- lipid-solubilizing the synthetic mRNA in a lipid or lipid derivative carrier, thereby forming a lipid-solubilized mRNA;
- obtaining intraoperatively a bone harvest sample;
- incubating intraoperatively the lipid-solubilized mRNA and the bone harvest sample, whereby the bone harvest sample internalizes at least a portion of the lipid-solubilized mRNA, thereby forming activated BMPR material;
- and
- delivering intraoperatively the activated BMPR material to a bone fusion bed.
3 more elements
A method comprising:
- obtaining a bone harvest sample during a surgical procedure;
- incubating the bone harvest sample and a lipid-solubilized synthetic messenger ribonucleic acid (mRNA) encoding at least for a bone morphogenetic protein receptor (BMPR) during the surgical procedure, whereby the bone harvest sample internalizes at least a portion of the lipid-solubilized mRNA, thereby forming activated BMPR material;
- and
- delivering the activated BMPR material to a bone fusion bed during the surgical procedure.
1 more element
Dependencies are inferred from the claim text.