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US 2026/0209769 A1Published application
Small rna medicament for prevention and treatment of inflammation-related diseases and combination thereof
AssigneeBeijing Baishihekang Pharmaceutical Technology (Bsjpharma) Co., Ltd
InventorsChengyu JIANG, Dandan ZHAO, Yuhao QIN, Cong ZHANG, Yexuan LIN
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Abstract
Provided is a small RNA, a composition comprising the small RNA, a method for using same and use of same. The small RNA or composition can inhibit the ability of any one or more of pathways or genes listed in Table 3, or decrease or down regulate the expression level of IL-1 beta, IL-6, and/or TNF-alpha in vitro or in vivo, or treat or prevent IL-1beta, IL-6, and/or TNF-alpha related diseases and/or increase cell viability in a subject.
Claims20
A small RNA comprising:
- (A) The sequence shown in any one of SEQ ID NO. 1-19 and 21-222, or
- complementary sequence thereof;
- (B) A sequence with at least 80%-98% identity with the sequence shown in (A);
- (C) A sequence that hybridizes to the sequence shown in (A);
- (D) A sequence obtained from the sequence shown in (A) by addition, deletion, replacement or insertion of one or more, such as 2, 3, 4, 5, 6, 7, 8 or 9 base(s);
- or
- (E) A precursor or modified variant of the sequence shown in (A), (B), (C) or (D).
4 more elements
Dependencies are inferred from the claim text.