Means and methods to target endogenous condensates
AssigneesMax-Planck-Gesellschaft Zur FöRderung Der Wissenschaften E. V., Massachusetts Institute of Technology
InventorsIbrahim CISSÉ, Choongman LEE
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Abstract
The invention relates to a system for modifying a target biomolecule that is associated to an endogenous intracellular condensate formed by an intracellular protein comprising an Intrinsically Disordered Region (IDR), or to a system for modifying a chemical or physical property of an endogenous intracellular condensate. The system of the invention comprises as its minimal components an IDR polypeptide sequence tract comprising the Intrinsically Disordered Region of the intracellular protein, and an effector polypeptide domain capable of covalently modifying said target biomolecule.
Claims14
A system for covalently modifying a target,
- the target being associated to an endogenous intracellular condensate formed by an intracellular protein comprising an Intrinsically Disordered Region (IDR),
- or a system for modifying a chemical or physical property of an endogenous intracellular condensate,
- said system comprising:
- a. an IDR sequence tract comprising said Intrinsically Disordered Region and
- b. an effector domain capable of modifying said target;
- wherein the IDR sequence tract and the effector domain are located on distinct polypeptide molecules that can be induced to associate in response to light.
Dependencies are inferred from the claim text.