Method for selecting stem cells with enhanced cartilage differentiation capability and cell therapy product comprising same
OwnerMi Jin Kim, Jong Chan Ahn +3inventors
InventorsMi Jin Kim, Jong Chan Ahn, Seong Soo Song, Seung Hee Lee, Kyung Sun Kang
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Abstract
The present invention pertains to a method for selecting stem cells with enhanced cartilage differentiation capability, a cell therapy product comprising the stem cells selected by the selection method, and a production method therefor.
Claims8
A method for manufacturing a cell therapy product, the method comprising:
- measuring the concentration of TGF-β1 within a culture of stem cells subcultured for 2 passages or fewer;
- and
- isolating stem cells secreting TGF-β1, the concentration of which exceeds 1046.7 pg/1×105 cells within the culture.
A pharmaceutical composition for the prevention or treatment of arthritis, the pharmaceutical composition comprising, as an active ingredient, stem cells or cells differentiated therefrom,
- wherein the cells are stem cells secreting TGF-β1, the concentration of which exceeds 1046.7 pg/1×105 cells within a culture of stem cells subcultured for 2 passages or fewer, or cells proliferated or differentiated therefrom.
A method for selecting stem cells for the prevention or treatment of arthritis, the method comprising:
- measuring the concentration of TGF-β1 within a culture of stem cells subcultured for 2 passages or fewer;
- and
- selecting, as stem cells for the prevention or treatment of arthritis, stem cells secreting TGF-β1, the concentration of which exceeds 1046.7 pg/1×105 cells within the culture.
Dependencies are inferred from the claim text.