Composition and method for ex vivo expansion of stem cell memory t cells

Abstract

The present disclosure provides a composition for ex vivo expansion of stem cell memory T cells, comprising: a first composition, which includes CD3, CD28, interleukin-2 (IL-2), interleukin-7 (IL-7) and interleukin-15 (IL-15); and a second composition, which includes interleukin-2, interleukin-7, and interleukin-15. The present disclosure also provides a method for ex vivo expansion of stem cell memory T cells, comprising: culturing mononuclear cells in a medium containing the first composition to obtain activated T cells; culturing the activated T cells in a medium containing the second composition to obtain a first cell population; and culturing the obtained first cell population in a medium containing a third composition to obtain a second cell population. Therefore, the composition and method for ex vivo expansion of the stem cell memory T cells provided by the present disclosure may be applied in clinical fields related to immunotherapy.

Dependencies are inferred from the claim text.