Bioprocessing system with automatic filter switching and rotary valve for use in a bioprocessing system

A bioprocessing system, comprising:

• a process vessel;
• a filtration assembly including a plurality of filter housings;
• a feed pump coupled to the plurality of filter housings for moving fluid between the process vessel and the filtration assembly;
• a retentate valve coupled within a retentate line between the process vessel and the plurality of filter housings, the retentate valve including a fluid passageway that is controlled to selectively direct movement of the fluid to at least one of the plurality of filter housings;
• a permeate valve coupled within a permeate line between the plurality of filter housings and a permeate pump;
• a pressure sensor disposed in the permeate line;
• and
• a controller coupled to the pressure sensor, the retentate valve, and the permeate valve, the controller executing instructions for actuating the retentate valve and the permeate valve to direct flow between the process vessel and a selected one of the plurality of filter housings, and to direct permeate flow from the selected one of the plurality of filter housings to the permeate pump, based on information received from the pressure sensor.