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US 2026/0209395 A1Published application
New Hyaluronan Hydrogels Chemically Crosslinked By MMP Inhibitors
AssigneesConsorzio Interuniversitario Nazionale Per La Scienza E Tecnologia Dei Materiali, Universita' Degli Studi Di Firenze, Università Degli Studi Di Siena
InventorsAgnese MAGNANI, Cristina NATIVI, Marco FRAGAI, Gemma LEONE, Marco CONSUMI, Simone PEPI, Oscar FRANCESCONI, Stefano ROELENS
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Abstract
The present invention describes a hyaluronan (HA) chemically crosslinked by a di-, quardri-octavalent matrix metallo-proteinases inhibitor (MMPi). These hydrogels can be used for both medical and cosmetic applications.
Claims15
A crosslinked hyaluronic acid (HA) derivative of formula (I)
- wherein
- n is in the range 2.5-25000;
- L is a bi- quadri- or octa-valent linker of formula (II)
- wherein
- m is an integer number selected from 0-4;
- r is an integer number selected from 1-7;
- p is an integer number selected from 1-3;
- R1 is H, OH, OAlk1-4, X, CX3, Ph, para-C6H4—F, OPh, CH2Ph, wherein X is a halogen;
- R2 is H or R3;
- R3 is selected in the group consisting of CH2CH2NH—, CH2CH2(CO)NHCH2CH2NH—, CH2CH2(CO)N(CH2CH2NH—)2;
- R4 is H, CH2OH, CH2SH, CH2CH2SMe, CH(CH3)2, CH(CH3)OH.
8 more elements
Dependencies are inferred from the claim text.