Single-domain antibody for inhibition of neutrophil elastase activity
AssigneesUniversite De Liege, Universite Catholique De Louv Ain, Vrije Universiteit Brussel
InventorsMireille DUMOULIN, Francisco MORALES YANEZ, Paola REDEGHIERI, Rita VANBEVER, Jessica VANDERSTRAETEN, Teresinha LEAL, Angelique MOTTAIS, Serge MUYLDERMANS, Cecile VINCKE
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Abstract
The present invention relates to a binding agent capable of specifically binding to and inhibiting competitively a neutrophil elastase, which binding agent comprises an immunoglobulin single variable domain (ISVD), as well as related products, methods, and uses, such as in particular methods and uses aimed at the prevention, treatment, or diagnostics of inflammatory diseases.
Claims20
A binding agent capable of specifically binding to and inhibiting a neutrophil elastase (NE),
- wherein the binding agent comprises an immunoglobulin single variable domain (ISVD) and the binding agent competes with Elastase Inhibitor 3 (EI3) for binding to NE.
Dependencies are inferred from the claim text.