Antibodies to carbohydrate antigens
AssigneeRamot at Tel-Aviv University Ltd.
InventorsVered PADLER-KARAVANI, Ron AMON, Ronit ROSENFELD
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Abstract
The present invention discloses novel monoclonal antibodies and functional fragments thereof that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity. The invention further provides compositions comprising the antibodies or fragments thereof as well as uses of the antibodies, fragments and compositions.
Claims18
A nucleic acid molecule encoding at least one chain of a monoclonal antibody or fragment thereof, wherein the monoclonal antibody or fragment thereof specifically binds to Sialyl Lewis A glycan (SLeA), comprises an antigen binding domain comprising a heavy-chain variable domain (VH) and a light-chain variable domain (VL) each comprising three complementarity determining regions (CDRs) wherein the VH-CDR 1, 2 and 3 comprise amino acid sequences SEQ ID NOs:
- 15, 12, and 8, respectively, and the VL-CDRs 1, 2 and 3 comprise amino acid sequences SEQ ID NOs:
- 9, 10 and 11, respectively.
Dependencies are inferred from the claim text.