Antibody compositions targeting non-phosphorylated alpha-synuclein aggregates
AssigneeHamad Bin Khalifa University
InventorsOmar El-Agnaf, Nour Khaled Majbour, Nishant Vaikath
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Abstract
The present specification provides a monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein and a hybridoma producing it. Also disclosed are methods of generating antibodies that specifically binds aggregated, non-phosphorylated α-synuclein and uses thereof. Uses of anti-α-synuclein antibody in detection and diagnostic assays, and for prophylaxis or therapy of α-synuclein-associated neurodegenerative diseases, are also disclosed.
Claims16
A nucleic acid molecule comprising a sequence encoding a monoclonal antibody that specifically binds aggregated, non-phosphorylated α-synuclein comprising a heavy chain variable region (VH) and a light chain variable region (VL).
Dependencies are inferred from the claim text.