Novel light-sensitive channel protein vr2.0 and uses thereof
AssigneeZhongmou Therapeutics Co., Ltd.
InventorYin SHEN
Life of this patent
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Abstract
The application provides a novel light-sensitive channel protein VR2.0 and uses thereof. The light-sensitive channel protein VR2.0 series provided in this application demonstrates profound therapeutic effects in the treatment of retinal photoreceptor cell degenerative diseases. This novel light-sensitive channel protein exhibits enhanced photosensitivity, fast kinetics, and reduced side effects. Under identical photostimulation conditions, VR2.0 demonstrates faster response frequencies while maintaining stable photocurrent signals even during high-frequency stimulation. This application provides a better optogenetic therapeutic option for retinal photoreceptor cell degenerative diseases, and has significant application and promotion value.
Claims20
A light-sensitive channel protein comprising any one of the following PsCatCh variants:
- (1) a protein obtained by truncating 1-33 amino acids at the N-terminus of the reference protein shown in SEQ ID NO. 1;
- (2) a protein obtained by truncating 1-29 amino acids at the C-terminus of the reference protein shown in SEQ ID NO. 1;
- (3) a protein obtained by mutations introduced around the retinal binding site of the reference protein shown in SEQ ID NO. 1;
- (4) a combination of any two or three of the above (1), (2), and (3);
- or
- (5) a protein having more than 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with the proteins described in (1), (2), (3), or (4).
Dependencies are inferred from the claim text.