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US 2026/0209276 A1Published application
GhR-BINDING PEPTIDE AND COMPOSITION COMPRISING SAME
AssigneePeptiDream Inc.
InventorsTatsuya TOMIYAMA, Haruaki KURASAKI, Katsuma MATSUI, Yoshiaki MASUDA, Masataka UMITSU
Life of this patent
Estimating the term…
Abstract
The present technology generally relates to peptides that bind to the growth hormone receptor (GhR), to peptides that bind to the GhR and have antagonistic activity, and to compositions comprising such peptides.
Claims18
A method for treatment of a disease associated with human growth hormone hypersecretion, comprising:
- administering a peptide or the salt thereof to a patient having a disease associated with human growth hormone hypersecretion, the peptide or the salt thereof having the following amino acid sequence:
- (SEQ ID NO:
- 1)
- X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13
- wherein:
- X1 is an amino acid having an aromatic ring or a substitution thereof;
- X2 is an N-alkyl amino acid or a modification thereof;
- X3 and X4 are each a branched-chain amino acid;
- X5 is any amino acid;
- X6 is N;
- X7 is W or a substitution thereof;
- X8 is an amino acid having an aromatic ring or a substitution thereof;
- X9 is K or a substitution thereof, or is R or a substitution thereof;
- X10 is an amino acid having an aromatic ring or a substitution thereof;
- X11 is A or a substitution thereof, or is K or a substitution thereof;
- X12 is any amino acid;
- and
- X13 is C;
- and
- wherein the peptide or the salt thereof comprises none, one, two or three substitution, deletion, addition, or insertion, and wherein the peptide or the salt thereof has avidity for the growth hormone receptor.
17 more elements
A method for inhibiting growth hormone receptor in a subject, comprising:
- administering a peptide or the salt thereof to the subject, the peptide or the salt thereof having the following amino acid sequence:
- (SEQ ID NO:
- 1)
- X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13
- wherein:
- X1 is an amino acid having an aromatic ring or a substitution thereof;
- X2 is an N-alkyl amino acid or a modification thereof;
- X3 and X4 are each a branched-chain amino acid;
- X5 is any amino acid;
- X6 is N;
- X7 is W or a substitution thereof;
- X8 is an amino acid having an aromatic ring or a substitution thereof;
- X9 is K or a substitution thereof, or is R or a substitution thereof;
- X10 is an amino acid having an aromatic ring or a substitution thereof;
- X11 is A or a substitution thereof, or is K or a substitution thereof;
- X12 is any amino acid;
- and
- X13 is C;
- and
- wherein the peptide or the salt thereof comprises none, one, two or three substitution, deletion, addition, or insertion, and wherein the peptide or the salt thereof has avidity for the growth hormone receptor.
17 more elements
Dependencies are inferred from the claim text.