Synthetic Peptide And Construct
AssigneeToagosei Co., Ltd.
InventorsNahoko Baileykobayashi, Tetsuhiko Yoshida
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Abstract
A novel synthetic peptide with cell membrane permeability is provided. The synthetic peptide disclosed herein includes any of the following amino acid sequences: (1) an amino acid sequence in which two or more minimum constituent units are bonded continuously in series, the minimum constituent unit being PD (proline residue-aspartic acid residue) or PE (proline residue-glutamic acid residue); and (2) an amino acid sequence in which one to three glycine residues are bonded to a C-terminus of (1) the amino acid sequence.
Claims6
A synthetic peptide for transferring a target foreign substance from outside a eukaryotic cell into at least a cytoplasm of the cell, the synthetic peptide comprising any of the following amino acid sequences:
- (1) an amino acid sequence in which two or more minimum constituent units are bonded continuously in series, the minimum constituent unit being PD (proline residue-aspartic acid residue) or PE (proline residue-glutamic acid residue);
- and
- (2) an amino acid sequence in which one to three glycine residues are bonded to a C-terminus of (1) the amino acid sequence.
A synthetic peptide for transferring a target foreign substance from outside a eukaryotic cell into at least a cytoplasm of the cell, the synthetic peptide comprising any of the following amino acid sequences:
- (SEQ ID No.:
- 1)
- PDPD;
- (SEQ ID No.:
- 2)
- PEPE;
- (SEQ ID No.:
- 7)
- PDPEG;
- (SEQ ID No.:
- 8)
- PEPDG;
- (SEQ ID No.:
- 9)
- PDPDPDPDPDPDG;
- (SEQ ID No.:
- 10)
- PEPEPEPEPEPEG;
- and
- (SEQ ID No.:
- 11)
- PDPEPDPEPDPEG.
Dependencies are inferred from the claim text.