Heterocyclic propyl amine modulators of monoaminergic transporters
OwnerAlan C. GIBBS, Robert B. PERNI +2inventors
InventorsAlan C. GIBBS, Robert B. PERNI, Tanweer A. KHAN, Glenn SHORT
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Abstract
Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, V W, X, Y, and Z are defined herein. Also provided are pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or a pharmaceutically acceptable salt thereof, e.g., in the treatment of a mental heal disease or disorder.
Claims41
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- V and W independently are C or N;
- X, Y, and Z independently are O, S, CR6, N, or NR7;
- wherein R6 is hydrogen, deuterium, halogen, alkyl, fluoroalkyl, O-alkyl, O-fluoroalkyl, aryl, or benzyl;
- wherein R7 is hydrogen, deuterium, alkyl, or fluoroalkyl;
- R1 and R2 independently are hydrogen, deuterium, halogen, alkyl, fluoroalkyl, O-alkyl, or O-fluoroalkyl;
- or
- R1 and R2 together are carbonyl;
- or
- R1 and R2 together with the carbon atom to which they are attached form a cycloalkyl;
- R3 is hydrogen, deuterium, halogen, alkyl, fluoroalkyl, O-alkyl, or O-fluoroalkyl;
- and
- R4 and R5 independently are hydrogen, deuterium, alkyl, or fluoroalkyl;
- or
- one of R4 or R5 is
- wherein R8 and R9 independently are alkyl;
- and
- wherein n is an integer from 2-5.
A compound of Formula (I-A):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R4 and R5 independently are hydrogen, deuterium, C1-C6 alkyl or C1-C6 fluoroalkyl;
- or
- one of R4 or R5 is
- wherein R8 and R9 independently are C1-C6 alkyl.
A compound of Formula (I-B):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R4 and R5 independently are hydrogen, deuterium, C1-C6 alkyl or C1-C6 fluoroalkyl;
- or
- one of R4 or R5 is
- wherein R8 and R9 independently are C1-C6 alkyl.
A compound of Formula (I-C):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R4 and R5 independently are hydrogen, deuterium, C1-C6 alkyl or C1-C6 fluoroalkyl;
- or
- one of R4 or R5 is
- wherein R8 and R9 independently are C1-C6 alkyl.
A compound of Formula (I-D):
- or a pharmaceutically acceptable salt thereof,
- wherein,
- R4 and R5 independently are hydrogen, deuterium, C1-C6 alkyl or C1-C6 fluoroalkyl;
- or
- one of R4 or R5 is
- wherein R8 and R9 independently are C1-C6 alkyl.
A compound, or a pharmaceutically acceptable salt thereof, selected from:
Dependencies are inferred from the claim text.