Amidinourea derivatives and their use in the treatment of cancer

A compound of formula (I)

• wherein
• R1 and R2 are independently selected from H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, heterocyclyl having 5 to 10 ring atoms, aryl having 6 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, and C7-C16 aralkyl, said alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, heterocyclyl, aryl, heteroaryl and aralkyl being optionally substituted with one or more substituents preferably selected from oxo, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, —OH, —OR, —NR′R″, —NO2, —CN and —(CO)—R;
• or R1 and R2, together with the carbon-carbon double bond between them, form a 6 to 10 membered aryl or heteroaryl ring, said aryl and heteroaryl being optionally substituted with one or more substituents preferably selected from oxo, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, —OH, —OR, —NR′R″, —NO2, —CN and —(CO)—R;
• Ring A is selected from aryl having 6 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, C3-C6 cycloalkyl, and heterocyclyl having 5 to 10 ring atoms, said aryl, heteroaryl, cycloalkyl and heterocyclyl being optionally substituted with one or more substituents preferably selected from oxo, halogen, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, —OH, —OR, —NR′R″, —NO2, —CN and —(CO)—R;
• each R is independently selected from H, C1-C6 alkyl, OH, C1-C6 alkoxy and —NR′R″;
• and
• each R′ and R″ is independently selected from H and C1-C6 alkyl, and pharmaceutically acceptable salts thereof.