Isoxazoline-substituted benzamide compound and application thereof

An isoxazoline-substituted benzamide compound as shown in Formula I, a stereoisomer and an agriculturally or veterinarily acceptable salt thereof:

• wherein, X represents hydrogen, halogen, alkoxy or alkylthio;
• Y represents halogen or haloalkyl;
• Z and Z1 each independently represent hydrogen, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl or cyano;
• P and P1 each independently represent CH or N;
• Q and Q1 each independently represent hydrogen, halogen, hydroxyl, cyano, amino, nitro, formyl, cyanoalkyl, hydroxyalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkylthio, alkylamino, haloalkoxy, haloalkylthio, alkylcarbonyl, alkoxycarbonyl, alkoxyalkyl, haloalkoxyalkyl, alkylaminoalkyl, aryl, heterocyclyl, arylalkyl or heterocyclylalkyl;
• wherein, the “alkyl”, “alkenyl” or “alkynyl” are each independently unsubstituted or substituted by at least one group of halogen, —OR1, —SR1, —(CO)OR1, —(CO)N(R1)2, —(SO2)R1 or —N(R1)2;
• the “cycloalkyl”, “cycloalkylalkyl”, “aryl”, “heterocyclyl”, “arylalkyl” or “heterocyclylalkyl” are each independently unsubstituted or substituted by at least one group selected from oxo, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, cycloalkyl substituted by alkyl, —OR1, —SR1, —(CO)OR1, —(SO2)R1, —N(R1)2 or —O-alkyl-(CO)OR1, or two adjacent carbon atoms on the ring form a fused ring with —OCH2CH2— or —OCH2O— that is unsubstituted or substituted by halogen;
• M represents hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl,
• wherein, the “alkyl” “alkenyl” or “alkynyl” are each independently unsubstituted or substituted by at least one group selected from halogen, cyano, nitro, cycloalkyl, trialkylsilyl, cycloalkenyl, heterocyclyl, aryl,
• the “cycloalkyl”, “cycloalkenyl”, “heterocyclyl” or “aryl” are each independently unsubstituted or substituted by at least one group selected from oxo, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, cycloalkyl substituted by alkyl, —OR1, —SR1, —(CO)OR1, —(SO2)R1, —N(R1)2 or —O-alkyl-(CO)OR1, or two adjacent carbon atoms on the ring form a fused ring with —OCH2CH2— or —OCH2O— that is unsubstituted or substituted by halogen;
• R represents hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl,
• wherein, the “alkyl”, “alkenyl” or “alkynyl” are each independently unsubstituted or substituted by at least one group selected from halogen, cyano, nitro, cycloalkyl, trialkylsilyl, cycloalkenyl, heterocyclyl, aryl,
• the “cycloalkyl”, “cycloalkenyl”, “heterocyclyl” or “aryl” are each independently unsubstituted or substituted by at least one group selected from oxo, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, cycloalkyl substituted by alkyl, —OR1, —SR1, —(CO)OR1, —(SO2)R1, —N(R1)2 or —O-alkyl-(CO)OR1, or two adjacent carbon atoms on the ring form a fused ring with —OCH2CH2— or —OCH2O— that is unsubstituted or substituted by halogen;
• X11 each independently represents hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocyclyl, heterocyclylalkyl, aryl or arylalkyl;
• wherein, the “alkyl”, “alkenyl” or “alkynyl” are each independently unsubstituted or substituted by at least one group of halogen, —OR1, —SR1, —(CO)OR1, —(SO2)R1 or —N(R1)2;
• the “cycloalkyl”, “cycloalkylalkyl”, “cycloalkenyl”, “cycloalkenylalkyl”, “heterocyclyl”, “heterocyclylalkyl”, “aryl” or “arylalkyl” are each independently unsubstituted or substituted by at least one group selected from oxo, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, cycloalkyl substituted by alkyl, —OR1, —SR1, —(CO)OR1, —(SO2)R1, —N(R1)2 or —O-alkyl-(CO)OR1, or two adjacent carbon atoms on the ring form a fused ring with —OCH2CH2— or —OCH2O— that is unsubstituted or substituted by halogen;
• X12 each independently represents alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heterocyclyl, heterocyclylalkyl, aryl or arylalkyl;
• wherein, the “alkyl”, “alkenyl” or “alkynyl” are each independently unsubstituted or substituted by at least one group of halogen, —OR1, —SR1, —(CO)OR1, —(SO2)R1 or —N(R1)2;
• the “cycloalkyl”, “cycloalkylalkyl”, “cycloalkenyl”, “cycloalkenylalkyl”, “heterocyclyl”, “heterocyclylalkyl”, “aryl” or “arylalkyl” are each independently unsubstituted or substituted by at least one group selected from oxo, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, cycloalkyl substituted by alkyl, —OR1, —SR1, —(CO)OR1, —(SO2)R1, —N(R1)2 or —O-alkyl-(CO)OR1, or two adjacent carbon atoms on the ring form a fused ring with —OCH2CH2— or —OCH2O— that is unsubstituted or substituted by halogen;
• X13 and X14 each independently represent hydrogen, halogen, cyano, alkoxy, alkoxyalkyl, alkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, or the CX13X14 group together forms an unsubstituted or substituted ring structure, or the NX13X14 group together forms an unsubstituted or substituted heterocyclyl with nitrogen atom at 1-position;
• wherein, the “alkyl”, “alkenyl” or “alkynyl” are each independently unsubstituted or substituted by at least one group of halogen, —OR1, —SR1, —(CO)OR1, —(SO2)R1 or —N(R1)2;
• the “cycloalkyl”, “cycloalkylalkyl”, “cycloalkenyl”, “cycloalkenylalkyl”, “aryl”, “arylalkyl”, “heterocyclyl” or “heterocyclylalkyl” are each independently unsubstituted or substituted by at least one group selected from oxo, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, cycloalkyl substituted by alkyl, —OR1, —SR1, —(CO)OR1, —(SO2)R1, —N(R1)2 or —O-alkyl-(CO)OR1, or two adjacent carbon atoms on the ring form a fused ring with —OCH2CH2— or —OCH2O— that is unsubstituted or substituted by halogen;
• R1 each independently represents hydrogen, alkyl, haloalkyl, phenyl or phenyl substituted by at least one group selected from halogen, cyano, nitro, alkyl, haloalkyl, alkoxycarbonyl, alkylthio, alkylsulfonyl, alkoxy or haloalkoxy.