Composition for preventing or treating retinal diseases
AssigneesSeoul National University Hospital, Seoul National University R&Db Foundation
InventorsKyu Hyung Park, Kwangsic Joo, Seung Woo Choi, Gyeong Yun Jeon, Minji Kim
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Abstract
The present specification discloses a novel composition for preventing or treating retinal diseases. In one aspect, compounds in the present invention are extremely effective in protecting cells against the cytotoxicity of all-trans-retinal, inhibiting cellular aging, and inhibiting intracellular reactive oxygen species, and thus can be used in therapeutic agents for retinal diseases such as hereditary macular degeneration and age-related macular degeneration.
Claims11
A method for preventing, ameliorating, or treating retinal diseases, comprising administrating an effective amount of one or more compounds represented by the following General Formulas 1 to 5:
- wherein R1 to R17 of General Formulas 1 to 5 are each a substituent selected from the group consisting of a hydrogen, a deuterium, a halogen atom, a hydroxyl group, a cyano group, an amino group, an amido group, a nitro group, a substituted or unsubstituted (C1-C30) alkyl group, a substituted or unsubstituted (C3-C30) cycloalkyl group, a substituted or unsubstituted (C1-C30) heteroalkyl group, a substituted or unsubstituted (C2-C30) heterocycloalkyl group, a substituted or unsubstituted (C6-C30) aryl (C1-C30) alkyl group, an alkoxy group, an aryloxy group, a silyl group, a substituted or unsubstituted (C2-C30) alkenyl group, a substituted or unsubstituted (C2-C30) cycloalkenyl group, a substituted or unsubstituted (C1-C30) heteroalkenyl group, a substituted or unsubstituted (C2-C30) alkynyl group, a substituted or unsubstituted (C6-C30) aryl group, a substituted or unsubstituted (C2-C30) heteroaryl group, an acyl group, a carboxylic acid, an ether, an ester, a nitrile, an isonitrile, a sulfanyl group, a sulfinyl group, a sulfonyl group, a phosphino group, and combinations thereof.
Dependencies are inferred from the claim text.