Antigenic peptide having multiple kras variant peptides linked thereto, nucleic acid encoding the same, and use thereof
AssigneeHanmi Pharm. Co., Ltd.
InventorsYu Yon KIM, Inn Ah KIM, Joo Young DONG, Seung Hyun SHIN, Ji Hee LEE, Chang Gyu LIM, Seong Ju JEONG, Young Jin HAN, Yong Ho HEO
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Abstract
Provided are an antigenic peptide linked to multiple KRAS variant peptides, an mRNA encoding the same, a DNA encoding the same, an immunogenic composition including an antigenic peptide linked to multiple KRAS variant peptides or an mRNA encoding the same, and a method of inducing an immune response to KRAS variant peptides in a subject.
Claims21
1-20. (canceled)
An antigenic peptide in which two or more KRAS variant peptides selected from the group consisting of KRAS variant peptides are linked, wherein the antigenic peptide comprises G12C, G12D, and G13D variant peptides.
An mRNA encoding the antigenic peptide of claim 1.
The mRNA of claim 11, comprising the nucleotide sequence of SEQ ID NO:
- 2, 6, 14, 15, 296, 297, 298, 299, or 300.
Dependencies are inferred from the claim text.