Vaginal microbiota compositions for use in infertility
OwnerJohan E.T. VAN HYLCKAMA VLIEG, Elleke BOSMA +3inventors
InventorsJohan E.T. VAN HYLCKAMA VLIEG, Elleke BOSMA, Brynjulf MORTENSEN, Kevin DELONG, Laura ENSIGN
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Abstract
The invention relates to substantially complete vaginal microbiota preparations for treating infertility and therapeutic methods to do so.
Claims24
A method of treating an infertile female subject exhibiting a dysbiotic microbiota in the genitourinary tract, said method comprising administering to the subject an effective amount of a composition to the genitourinary tract to treat infertility, wherein the composition comprises a substantially complete vaginal microbiota preparation comprising:
- (i) one, two, three or four bacterial species from the genus Lactobacillus, selected from Lactobacillus crispatus, Lactobacillus iners, Lactobacillus jensenii, Lactobacillus gasseri, which comprise about 80-99.9% of all detectable bacterial species of the preparation;
- and
- (ii) less than 5% of Gardnerella spp., Atopobium spp., and Prevotella spp.
2-3. (canceled)
A method of increasing the rate of pregnancy and/or live births, e.g., by promoting embryo implantation and/or embryo retention, in a population of female subjects, optionally a population of infertile female subjects, wherein each of the subjects in the population exhibits a dysbiotic microbiota in the genitourinary tract, said method comprising administering to each of the subjects an effective amount of a composition to the genitourinary tract to increase the rate of pregnancy and/or live births, wherein the composition comprises:
- a substantially complete vaginal microbiota preparation comprising:
- (i) one, two, three or four bacterial species from the genus Lactobacillus, selected from Lactobacillus crispatus, Lactobacillus iners, Lactobacillus jensenii, Lactobacillus gasseri, which comprise about 80-99.9% of all detectable bacterial species of the preparation;
- and
- (ii) less than 5% of Gardnerella spp., Atopobium spp., and Prevotella spp.;
- and
- wherein the rate of pregnancy and/or live births is increased in the population of female subjects being administered the composition relative to a control population.
A method of reducing the rate of pregnancy loss (e.g., miscarriage) in a population of female subjects, optionally a population of infertile female subjects, wherein each of the subjects in the population exhibits a dysbiotic microbiota in the genitourinary tract, said method comprising administering to each of the subjects an effective amount of a composition to the genitourinary tract to reduce the rate of pregnancy loss, wherein the composition comprises:
- a substantially complete vaginal microbiota preparation comprising:
- (i) one, two, three or four bacterial species from the genus Lactobacillus, selected from Lactobacillus crispatus, Lactobacillus iners, Lactobacillus jensenii, Lactobacillus gasseri, which comprise about 80-99.9% of all detectable bacterial species of the preparation;
- and
- (ii) less than 5% of Gardnerella spp., Atopobium spp., and Prevotella spp.;
- and
- wherein the rate of pregnancy loss is reduced in the population of female subjects being administered the composition relative to a control population.
(canceled)
15-20. (canceled)
30-102. (canceled)
Dependencies are inferred from the claim text.