Nanostructured aqueous formulation of propolis extract and the uses thereof
AssigneesApis Vida IndúStria E ComéRcio De Produtos FarmacêUticos Ltda., Universidade de Sao Paulo-USP
InventorsPriscyla Daniely MARCATO GASPARI, Jairo KENUPP BASTOS, Iasmin Rosanne SILVA FERREIRA, Thais Fernanda MATIAZZI CORTEZ, Luiz Henrique MATIAZZI, Victor PENA RIBEIRO
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Abstract
A nanostructured aqueous formulation containing a high content of propolis extract, in particular Brazilian green or red propolis extract, intended for use in pharmaceutical, food, cosmetic and veterinary formulations. The bioactives present in the propolis extract are responsible for the antioxidant, anti-inflammatory, anti-tumour and antiviral activities thereof, which are enhanced and protected by the encapsulation of the extract in the lipid nanostructure.
Claims12
A nanostructured lipid formulation of propolis extract comprising:
- an oily phase consisting of 0.5 to 20%, of oil (lipid), 5 to 12%, of propolis extract, and optionally, 8 to 18%, of lipophilic surfactants;
- an aqueous phase consisting of 12 to 35%, 16 to 30% of hydrophilic surfactant, and water qsp with a pH between 6 and 9;
- wherein the mixing of the aqueous phase with the oily phase occurs under agitation of 400-1500 rpm at a temperature of 25-50° C.
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Dependencies are inferred from the claim text.