Heparan sulfate and its mimetics as chemokine inhibitors
AssigneeIndian Institute of Science Education and Research
InventorsRaghavendra KIKKERI, N. Vijendra KUMAR, Chethan D SHANTHAMURTHY, Prashant JAIN, Rakesh RAIGAWALI, Vered PADLER-KARAVANI, Shani LEVIATAN BEN-ARYE
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Abstract
The present invention relates to a heparan sulfate compound of formula (I) & (II) or a pharmaceutically acceptable salt thereof and pharmaceutical composition containing them. The present invention also relates to a process for preparing the compound of formula (I) & (II) or a pharmaceutically acceptable salt thereof and use of the compound of formula (I) & (II) or a pharmaceutically acceptable salt thereof as chemokine inhibitors
Claims11
A heparin sulfate compound of formula (I) or a stereoisomer, a tautomer, a conformer, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof;
- wherein:
- R1 is —(CH2)3NH2;
- R4 is H or S03;
- R4a is H or S03;
- R5 is NH2 or NHCOCH3;
- and R6 is H, SO3 and PO42−.
A heparin sulfate compound of formula (II) or a stereoisomer, a tautomer, a conformer, a pharmaceutically acceptable salt, a homooligosaccharides or a pharmaceutically acceptable solvate thereof;
- wherein:
- R1
- or cholestenol;
- R2 independently represents COOH or CH2OH;
- R3 independently represents H or SO3−;
- R4 independently represents H, SO3−;
- R5 independently represents OH, OSO3−,
- n is 0, 1, 2, or 3.
(canceled)
Dependencies are inferred from the claim text.