O/W composition emulsified with OSA starch for use in glycogen storage disease
AssigneeN.V. Nutricia
InventorsLeonardo Cornacchia, Janna Willemina Woestenenk, Bartholomeus Theodorus Gerardus Kompier, Evan Abrahamse, Simon David Anders
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Abstract
The invention relates to an emulsified O/W composition comprising emulsified lipid and OSA starch wherein the dry weight ratio of OSA starch to lipid is in the range from 1:3 to 1:5 and wherein less than 4 wt % protein is present based on total dry weight of the emulsified O/W composition and relates to the nutritional composition comprising the emulsified O/W composition and to the method of making these compositions and further relates to a nutritional composition for use in glycogen storage disease.
Claims13
-15. (canceled)
A method for preparing an emulsified oil-in-water (O/W) composition comprising emulsifying lipid with a first aqueous phase and octenyl succinic anhydride substituted starch (OSA) starch to obtain an emulsified O/W composition, wherein the dry weight ratio of OSA starch to lipid is in the range from 1:3 to 1:5 and wherein less than 4 wt % protein is present, based on total dry weight of the emulsified O/W composition and wherein the emulsified O/W composition comprises less than 10 wt % digestible carbohydrates based on total dry weight of the emulsified O/W composition, wherein the method further comprises:
- adding an encapsulating agent to the emulsified O/W composition;
- optionally adding a second aqueous phase comprising protein to the emulsified O/W composition and optionally pasteurizing the emulsified O/W composition;
- spray-drying the emulsified O/W composition, to obtain a spray-dried composition;
- wherein the spray-dried composition comprises lipid-containing particles which have a lipid core and wherein said lipid core is coated with OSA starch, and wherein the lipid core and OSA starch coating comprise less than 4 wt % protein altogether, based on total dry weight of the spray-dried composition.
A method for reducing and/or treating diabetes, glycogen storage disease (GSD), fatty acid oxidation disorder (FAOD) and/or idiopathic ketotic hypoglycemia (IKH) in a subject in need thereof wherein the method comprises administering the nutritional spray dried composition to the subject.
Dependencies are inferred from the claim text.