Combination therapy for cancer using ros-activated prodrugs and ros-amplifying therapeutics
AssigneeUWM Research Foundation, Inc.
InventorsXiaohua Peng, Taufeeque Ali
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Abstract
Described herein is an anticancer and anti-inflammatory combination therapy comprising one or more antineoplastic agents and one or more pro-oxidants. In one embodiment, the antineoplastic agent is not active in the absence of the pro-oxidant. In another embodiment, the pro-oxidant is administered prior to the antineoplastic agent to induce targeted activity of the antineoplastic agent.
Claims28
A combination therapeutic comprising:
- a therapeutically effective amount of one or more antineoplastic agents, or pharmaceutically acceptable salts or esters thereof, and
- a therapeutically effective amount of one or more pro-oxidants, or pharmaceutically acceptable salts or esters thereof.
A method for treating a disease or disorder, the method comprising:
- sequentially or simultaneously administering to a subject in need thereof
- a therapeutically effective amount of one or more antineoplastic agents, or pharmaceutically acceptable salts or esters thereof, and
- a therapeutically effective amount of one or more pro-oxidants, or pharmaceutically acceptable salts or esters thereof;
- and
- repeating the administration until the disease or disorder is treated, ameliorated, or symptoms are reduced.
Use of one or more antineoplastic agents and one or more pro-oxidants, or pharmaceutically acceptable salts or esters thereof, as a medicament for the treatment of cancer or an inflammatory disease in subject in need thereof.
A kit comprising:
- one or more antineoplastic agents, or pharmaceutically acceptable salts or esters thereof;
- one or more pro-oxidants, or pharmaceutically acceptable salts or esters thereof;
- optionally a device or means for administering the antineoplastic agent and pro-oxidant;
- optionally tamper resistant packaging;
- and
- optionally, a label or instructions for use thereof.
Dependencies are inferred from the claim text.