Polyphenolic Boronates and Use Thereof
AssigneesThe Medical College of Wisconsin, Inc., Aix-Marseille Universite
InventorsBalaraman Kalyanaraman, Micael Joël Hardy, Gang Cheng
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Abstract
The present disclosure provides polyphenolic boronates and mitochondria-targeted polyphenolic boronates and pharmaceutical compositions thereof. The present compounds may be useful for treating cancer and reducing or inhibiting cancer cell growth. The present compounds may be useful for reducing or analyzing reactive oxygen and nitrogen species in tumor microenvironment of a cancer. The present compounds may target mitochondria in carcer cells and have improved anti-tumor effect and reduced toxicity.
Claims22
A compound of formula (I) or (II),
- wherein
- one of R1 and R2 is H,
- the other of R1 and R2 is
- n is an integer from 1-20;
- and
- Z⊖ is a counterion.
(canceled)
20-25. (canceled)
Dependencies are inferred from the claim text.