Cannabidiol for the treatment of refractory seizures
AssigneeHarmony Biosciences Management, Inc.
InventorsJoseph Palumbo, Donna Gutterman, Terri Sebree
Life of this patent
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Abstract
Provided are methods of treating refractory seizures in a human subject, e.g., a child, that include administering an effective amount of cannabidiol (CBD), e.g., in a transdermal gel.
Claims28
A method of treating refractory seizures in a human subject suffering from an autism spectrum disorder (ASD), the method comprising:
- administering an effective amount of cannabidiol (CBD) to the human subject in need thereof to treat the refractory seizures.
The method according to any of the preceding claims, wherein the refractory seizures treated are selected from the group consisting of focal impaired awareness seizures (FIAS), generalized tonic-clonic seizures (GTCS), or focal to bilateral tonic-clonic seizures (FBTCS).
The method according to any of the preceding claims, wherein the CBD is administered transdermally.
The method according to any of the preceding claims, wherein the effective amount of CBD ranges from about 250 mg to about 1000 mg total daily.
The method according to any of the preceding claims, wherein the CBD is administered in a single daily dose.
The method according to any of the preceding claims, wherein the treatment includes an improvement in sleep-related impairment.
The method according to any of the preceding claims, wherein the CBD is a synthetic CBD.
The method according to any of the preceding claims, wherein the CBD is a pure CBD.
The method according to any of the preceding claims, wherein the cannabidiol is (−)-cannabidiol.
The method according to any of the preceding claims, wherein the CBD is formulated as a gel.
The method according to any of the preceding claims, wherein, upon beginning administering the effective amount of CBD, circadian rhythm is maintained or improved.
The method according to any of the preceding claims, wherein administering the effective amount of CBD does not become addictive.
The method according to any of the preceding claims, wherein, upon beginning administering the effective amount of CBD, the human subject experiences no excessive somnolence.
A method of treating refractory seizures in a human subject suffering from autism spectrum disorder (ASD) and sleep disturbance the method comprising:
- administering an effective amount of cannabidiol (CBD) to the human subject to treat the refractory seizures and sleep disturbance.
A method of treating refractory seizures in a child suffering from developmental and epileptic encephalopathies (DEE), the method comprising:
- administering an effective amount of cannabidiol (CBD) to the child, wherein the refractory seizures are treated in response to administration of CBD.
Dependencies are inferred from the claim text.