Compound and use thereof
AssigneeOnquality Pharmaceuticals China Ltd.
InventorsShilan LIU, Shiyi ZHANG, Chengxu ZHAO
Life of this patent
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Abstract
The present application relates to a compound as a CDK4/6 inhibitor is delivered to the gastrointestinal trac in a targeted manner. The present application further relates to a pharmaceutical composition comprising the compound, a method of using the compound for treating, preventing, or ameliorating gastrointestinal side effects caused by chemotherapy, and a method and intermediates for preparing the compound.
Claims70
A compound of formula (I), or a pharmaceutically acceptable salt, bioactive metabolite, solvate, hydrate, prodrug, racemate, enantiomer or stereoisomer thereof,
- wherein,
- n is 1, 2 or 3,
- R1 is selected from:
- hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl;
- R2, R3, R4, and R5 are each independently selected from:
- hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, and substituted or unsubstituted alkenyl;
- Or any two of R2, R3, R4 and R5 are joined to form a ring.
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Dependencies are inferred from the claim text.