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US 2026/0207585 A1Published application
Methods and compositions for the treatment of parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, and learning disorders
AssigneesCedars-Sinai Medical Center, Fortem Neurosciences, Inc.
InventorsMaya KORONYO, Keith L. BLACK, Jack KAVANAUGH, Larry COUTURE
Life of this patent
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Abstract
Provided are methods and compositions for the treatment of Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and learning disorders.
Claims22
A method of treating Parkinson's disease, Huntington's disease, ALS, or a learning disorder in a subject in need thereof, the method comprising administering to the subject a compound comprising an inhibitor of trimethylation of histone 3, lysine 9 (H3K9).
A method of inhibiting an enzyme selected from the group consisting of:
- ASH1L, MLL1 complex, MLL4 complex, NSD3, Set1b complex, SMYD2, SMYD3, SUV39H1, and SUV39H2, comprising contacting the enzyme with a compound having the structure of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein, p is 2, 3 or 4, and
- R1, R2, R3, R4, R5, R6, R16, and R18 are independently hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —Cl3, —CN, —CHO, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl.
Dependencies are inferred from the claim text.