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AssigneeSeoul National University R&Db Foundation
InventorsBum-Joon KIM, Yu-Min CHOI, Junghwa JANG, Ziyun KIM
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The present disclosure relates to: an antiviral composition comprising spiperone as a cccDNA inhibitor; and a pharmaceutical composition for the prevention or treatment of viral infection or hepatitis B, comprising spiperone as a cccDNA inhibitor. The antiviral composition comprising spiperone, of the present invention, has antiviral activity against a wide range of viruses in consideration of the cccDNA inhibitory efficacy and mechanism of action. Also, the pharmaceutical composition comprising spiperone has excellent cccDNA inhibitory efficacy, antiviral efficacy, and therapeutic efficacy against viruses, and thus can be effectively used for the prevention or treatment of viral infection such as hepatitis B. Also, spiperone has a synergistic effect with an existing antiviral agent, and thus is effective in treating viral infection.
A method for inhibiting or removing a viral cccDNA expression in a nucleus of a host cell, comprising administering spiperone or a pharmaceutically acceptable salt thereof to a subject in need thereof.
A method for inhibiting or removing a virus that produces cccDNA in a nucleus of a host cell, comprising administering spiperone or a pharmaceutically acceptable salt thereof to a subject in need thereof.
A method of preventing or treating virus infection, wherein a virus that produces cccDNA in the nucleus of a host cell, comprising administering spiperone or a pharmaceutically acceptable salt thereof to a subject in need thereof.
Dependencies are inferred from the claim text.