Method of Manufacturing a Hydrogel Useful for Preventing Post-Surgical Adhesions

A method of manufacturing a hydrogel comprising reacting the components:

• A) an isocyanate-terminated prepolymer obtained by reacting a mixture comprising:
• A1) a diisocyanate with a molar weight of 140 to 278 g/mol;
• A2) a polyalkylene oxide with an ethylene oxide content of ≥50 weight-%, calculated from the total weight of the polyalkylene oxide;
• B) a polyamine having a molecular weight of ≥200 g/mol;
• C) water;
• wherein
• the polyalkylene oxide A2) and/or the polyamine B) further comprise ester groups, expressed as —C(═O)—O— groups, in an amount of ≥0.51 weight-%, based on the total weight of polyalkylene oxide A2) or polyamine B), respectively,
• the average OH functionality of polyalkylene oxide A2) is greater than 2 and/or the average combined primary and secondary amine functionality of polyamine B) is greater than 2,
• the combined components A) and B) are present in an amount of >11.5 weight-%, based on the total weight of components A), B) and C).