Anti-dandruff compositions
AssigneeFirmenich SA
InventorsYang HUANG, Xue-Fei BAI, Ying ZHENG
Life of this patent
Estimating the term…
Abstract
The present invention relates to anti-dandruff compositions comprising one or more perfume compounds. The invention also relates to hair care products comprising such compositions as well as methods of treating dandruff using such compositions or products. The invention further relates to a method of identifying compositions useful for the treatment and/or prevention of dandruff.
Claims27
An anti-dandruff composition comprising one or more perfume compounds from the following:
- (A) a compound of formula (I)
- wherein
- RA is R1 wherein R1 is C4-C12 alkyl, C4-C5 alkenyl, or C4-C5 alkynyl;
- or
- wherein R3 is H, C1-C6 alkyl, or C1-C6 alkoxy;
- R4 is H, —OH, C1-C6 alkyl, or C1-C6 alkoxy;
- and A is a divalent radical selected from the group consisting of a bond, C1-C6 alkylene, or C2-C6 alkenylene;
- Z is C(═O) or CH2;
- RB is H, OH, or OR2, wherein R2 is C1-6 alkyl or (carbocyclyl)alkyl;
- and/or
- (B) (2E)-2-dodecenal, (E,E)-2,4-decadienal, (E)-2-undecenal, (Z)-2-decenal, (2E)-2,4-undecadienal, (2E)-2,4-dodecadienal, (4Z)-4-dodecenal, (4Z)-4,8-dimethyl-4,9-decadienal, (4E)-4,8-dimethyl-4,9-decadienal, (Z)-4-decenal, (E)-3,7-dimethyl-2,6-octadien-1-ol, indole, methyl 2,4-dihydroxy-3,6-dimethylbenzoate, geranium rose oil, 4-methyl-2-pentylpyridine, 3-(1,3-benzodioxol-5-yl)-2-methylpropanal, 4-formyl-2-methoxyphenyl 2-methylpropanoate, [(3,7-dimethyl-6-octen-1-yl)oxy]acetaldehyde, 3-(3,3-dimethyl-2,3-dihydro-1H-inden-5-yl)propanal, 3-(1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)propanal, 3-(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)propanal, 3-(4,4-dimethyl-1-cyclohexen-1-yl)propanal, 3,6,7-trimethyl-2,6-octadienal, (9E)-9-undecenal, (9Z)-9-undecenal, 2-methylbutyl salicylate, pentyl salicylate, pine siberian oil, (1′RS,2RS,2′RS,3RS,7′RS,8′RS)-3,4′-dimethylspiro[oxirane-2,9′-tricyclo[6.2.1.0~2,7~]undec[4]ene], (1′RS,2RS,2′RS,3RS,7′RS,8′RS)-3,5′-dimethylspiro[oxirane-2,9′-tricyclo[6.2.1.0~2,7~]undec[4]ene], (1RS,2RS,4RS,6SR,8RS,9RS,11E)-11-ethylidene-4-methyl-5-oxatetracyclo[7.2.1.0~2,8~.0~4,6~]dodecane, (1 RS,2RS,4SR,6RS,8RS,9RS,10E)-10-ethylidene-4-methyl-5-oxatetracyclo[7.2.1.0~2,8~.0~4,6~]dodecane, 3-(2-ethylphenyl)-2,2-dimethylpropanal, (3E)-3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one, (1E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1-penten-3-one, (6RS,7RS)-3,5,5,6,7,8,8-heptamethyl-5,6,7,8-tetrahydro-2-naphthalenecarbaldehyde, 8-sec-butylquinoline, 6-sec-butylquinoline, (1 RS,2RS,7SR,8RS,9Z)-9-ethylidene-3-oxatricyclo[6.2.1.0~2,7~]undecane, (1 RS,2SR,7SR,8SR,10Z)-10-ethylidene-3-oxatricyclo[6.2.1.0~2,7~]undecane, (1 RS,2RS,7SR,8RS,9E)-9-ethylidene-3-oxatricyclo[6.2.1.0~2,7~]undecane, (1 RS,2SR,7SR,8SR,10E)-10-ethylidene-3-oxatricyclo[6.2.1.0~2,7~]undecane, allyl (3-methylbutoxy)acetate, allyl (2-methylbutoxy)acetate, (2Z)-5-[(1S,3R,4R)-2,3-dimethyltricyclo[2.2.1.0~2,6~]hept-3-yl]-2-methyl-2-penten-1-ol, (2Z)-2-methyl-5-[(1S,2R,4R)-2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl]-2-penten-1-ol, (Z)-3-hexenyl isobutyrate, (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyldodecahydronaphtho[2,1-b]furan, (2E)-2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, (2E)-2-ethyl-4-[(1R)-2,2,3-trimethyl-3-cyclopenten-1-yl]-2-buten-1-ol, 2,6-dimethyl-7-octen-2-ol, 3,5,6-trimethyl-3-cyclohexene-1-carbaldehyde, 2,4,6-trimethyl-3-cyclohexene-1-carbaldehyde, methyl 2,2-dimethyl-6-methylidenecyclohexanecarboxylate, 2-(6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-yl)ethyl acetate, cabreuva oil, elemi oil, 2-{(1 RS)-1-[(1SR)-3,3-dimethylcyclohexyl]ethoxy}-2-oxoethyl propionate, 2-{(1 RS)-1-[(1RS)-3,3-dimethylcyclohexyl]ethoxy}-2-oxoethyl propionate, 2-oxo-2-{[(1 RS,2RS)-2,6,6-trimethylcycloheptyl]oxy}ethyl propionate, 2-oxo-2-{[(1 RS,2SR)-2,6,6-trimethylcycloheptyl]oxy}ethyl propionate, ethyl (2E,4Z)-2,4-decadienoate, methyl 2-(methylamino)benzoate, 1,1′-oxydibenzene, 3-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, 4-(4-methyl-3-penten-1-yl)-3-cyclohexene-1-carbaldehyde, 1,4-dioxacycloheptadecane-5,17-dione, 3,7-dimethyl-6-octenal, tricyclo[5.2.1.0(2,6)]dec-3-en-8-yl propanoate, tricyclo[5.2.1.0(2,6)]dec-4-en-8-yl propanoate, (3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, (3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal, (6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-yl)propanal, 2/3/4-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, 2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)-1-cyclohexanol, (2E)-2-benzylideneoctanal, (R)-3,7-dimethyl-6-octenenitrile, cis-4-(2-methyl-2-propanyl)cyclohexyl acetate, trans-4-(2-methyl-2-propanyl)cyclohexyl acetate, 6,6-dimethoxy-2,5,5-trimethyl-2-hexene, 2,6,6-trimethyl-1,3-cyclohexadiene-1-carbaldehyde, (4E)-4-decenal, 2-methyldecanal, 2-methylundecanal, (R)-3,7-dimethyl-6-octenal, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol, 7-methyl-2H-1,5-benzodioxepin-3(4H)-one, tricyclo[5.2.1.0~2,6~]dec-3-en-8-yl acetate, tricyclo[5.2.1.0~2,6~]dec-4-en-8-yl acetate, 4-(2-methoxy-2-propanyl)-1-methylcyclohexene, 1-((2RS,3RS)-2,3,8,8-tetramethyl-1,2,3,4,5,6,7,8-octahydronaphthalen-2-yl)ethenone, 1-[(2RS,3RS,8aRS)-2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydro-2-naphthalenyl]ethenone, 1-[(2RS,3RS,8aRS)-2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydro-2-naphthalenyl]ethenone, (2,5-dimethyl-2,3-dihydro-1H-inden-2-yl)methanol, (2R)-2-methyl-4-[(1R)-2,2,3-trimethyl-3-cyclopenten-1-yl]-4-pentenal, and (2S)-2-methyl-4-[(1R)-2,2,3-trimethyl-3-cyclopenten-1-yl]-4-pentenal.
The composition of any of the previous claims, wherein the composition comprises one or more of the following compounds:
- p-menthan-7-ol, gamma-dodecalactone, methyl dihydrojasmonate, cinnamaldehyde, citral, lemongrass, cinnamon oil, delta-undecalactone, litsea cubeba oil, 10-undecenal, (2E,6Z)-2,6-nonadienal, (E)-3-phenyl-2-propenal, cinnamon oil ceylon, (+/−)-3-(4-methoxyphenyl)-2-methylpropanal, (2E)-2-dodecenal, (+/−)-3-(4-methoxyphenyl)-2-methylpropanal, (4E)-4-methyl-5-(4-methylphenyl)-4-pentenal, octanoic acid, (2Z)-3,7-dimethyl-2,6-octadienal, and (2E)-3,7-dimethyl-2,6-octadienal.
The composition of any of the previous claims, wherein the composition comprises:
- 1-dodecanol and 1-decanol.
A hair care product comprising a composition according to any of the previous claims.
A method of identifying a test compound or composition having use in treatment and/or prevention of dandruff, comprising
- (a) assaying whether the test composition reduces Malassezia furfur growth, and/or,
- (b) assaying whether the test composition reduces Malassezia globosa growth, and/or,
- (c) assaying whether the test composition disrupts Malassezia restricta growth, wherein a compound or composition which is positive in one or more assays is of use in/as anti-dandruff compositions.
Dependencies are inferred from the claim text.