Devices and methods for detecting mixing cloud locations

A device for detecting a location of a mixing cloud in a vessel of a subject, comprising a tubular member defining a plurality of lumens, including:

• a first lumen configured to allow blood to flow from a proximal end of the first tubular member to a distal end of the first tubular member;
• a second lumen configured to allow a second tubular member to be slidably received by the second lumen and draw a blood sample at a first location a first axial distance from the proximal end of the first tubular member;
• and
• a third lumen configured to allow a third tubular member to be slidably received by the third lumen and draw a blood sample at a second location at a second axial distance from the proximal end of the first tubular member, the second axial distance being different from the first axial distance.

A device for detecting a location of a mixing cloud in a vessel of a subject, comprising a tubular member defining a plurality of lumens, including:

• a first lumen configured to allow blood to flow from a proximal end of the first tubular member to a distal end of the first tubular member;
• a second lumen configured to allow a first pressure sensor to be operably connected to a controller through the second lumen, the first pressure sensor being positioned at or on an external surface of the first tubular member at a first location a first axial distance from the proximal end of the first tubular member;
• and
• a third lumen configured to allow a second pressure sensor to be operably connected to a controller through the third lumen, the second pressure sensor being positioned at or on the external surface of the first tubular member at a second location a second axial distance from the proximal end of the first tubular member, the second axial distance being different from the first axial distance.